Microneedling With Polynucleotides
Treatment Time
60-90 minutes (Area Dependent)
Recommended Sessions
6-12 Initial (Maintenance Advised)
Return to Work
Within 48 Hours
Comfort Level
Initial Warming Sensation - Numbing Applied
What is DermaPen Microneedling with Polynucleotides?
DermaPen Microneedling with Polynucleotides takes your microneedling treatment a step further. Alongside the DermaPen, we use a Polynucleotide (PDRN) product, a small vial of highly active skin-regenerating ingredients applied directly onto the skin during treatment. It is not an injection. Depending on your skin and what it needs, we will decide whether Polynucleotides are the right addition for you and apply them as part of the microneedling process
The micro-channels created by the DermaPen allow the Polynucleotides to absorb deeply into the skin, where they work to accelerate repair, stimulate collagen production, and restore visible vitality. This treatment is ideal for clients who want to go beyond standard microneedling and experience deeper, longer-lasting improvements in skin quality, firmness, and radiance.
What are Polynucleotides?
Polynucleotides (commonly referred to as PDRN or PolyDeoxyRiboNucleotide) are highly purified fragments of DNA that work at a cellular level to support the skin’s natural repair processes. At Eterno Clinic, the Polynucleotide product is supplied in a small vial and applied directly onto the surface of the skin during the microneedling treatment. It is not used for injection. The micro-channels created by the DermaPen allow the active ingredients to be absorbed effectively into the deeper layers of the skin, where they can provide the greatest benefit.
Once absorbed, Polynucleotides help to:
Stimulate fibroblast activity, encouraging the production of new collagen and elastin
Accelerate cellular repair and tissue regeneration
Improve skin hydration, density, and elasticity
Reduce the appearance of fine lines, deep wrinkles, and acne scarring
Counteract the effects of photoageing and environmental skin damage
Restore volume and firmness to sagging, devitalised skin
Unlike many active serums, Polynucleotides work with the skin’s own biology, making them well-tolerated and highly effective across a wide range of skin types and concerns.
Results
How Does the Treatment Work?
DermaPen Microneedling with Polynucleotides combines two powerful and complementary approaches into one cohesive treatment:
Step 1: DermaPen Microneedling
The DermaPen device uses a cartridge of ultra-fine, sterile needles to create thousands of precise micro-channels in the skin’s surface. This controlled stimulus triggers the skin’s natural healing cascade, stimulating the production of new collagen and elastin whilst restructuring existing skin cells. The result is a visibly rejuvenated complexion with improved texture and tone.
Step 2: Polynucleotide Application
The Polynucleotide product is applied directly onto the skin’s surface during the microneedling treatment. It is not injected. The micro-channels created by the DermaPen allow the active ingredients to be absorbed far beyond the skin’s surface and into the deeper dermal layers, where they can support cellular repair and regeneration most effectively. This targeted topical delivery significantly enhances the overall results when compared to microneedling with a standard serum alone.
Treatment Benefits
When DermaPen Microneedling is combined with Polynucleotides, clients can expect a comprehensive range of visible skin improvements, including:
- Visibly reduced acne scarring and post-inflammatory marks
- Diminished fine lines and deep wrinkles
- Firmer, tighter, and more lifted skin
- Improved skin texture, smoothness, and overall tone
- A brighter, more radiant and youthful complexion
- Restoration of lost volume and skin density
- Reduction in pigmentation and the effects of sun damage
- Deeply hydrated, plump, and revitalised skin
Because Polynucleotides actively support the skin’s repair mechanisms at a cellular level, results tend to improve progressively over the course of a treatment plan, with many clients noticing a significant transformation in overall skin health and quality.
Who is This Treatment Suitable For?
DermaPen Microneedling with Polynucleotides is suitable for all skin tones and is particularly well-suited to those experiencing:
- Acne scarring and post-inflammatory hyperpigmentation
- Fine lines, wrinkles, and visible signs of ageing
- Loss of skin firmness, elasticity, or volume
- Dull, devitalised, or photodamaged skin
- Uneven skin tone and texture
- Dehydrated or dry skin lacking density
This treatment is not recommended for clients with active acne, those who are pregnant or breastfeeding, or anyone with a known sensitivity to PDRN. A full consultation will be carried out prior to treatment to ensure suitability.
How Many Treatments Are Recommended?
For optimal results, we recommend an initial course of 6-8 treatments spaced 4-8 weeks apart. The precise number of sessions and intervals will be determined during your personalised skin consultation, based on your individual skin concerns, goals and response to treatment.
Following your initial course, maintenance treatments are recommended to preserve and build upon your results over time. Due to the corrective nature of this treatment, results can be long-lasting with consistent aftercare.
What to Expect During & After Treatment
Before the treatment begins, a topical numbing cream is applied to the treatment area to ensure your comfort. Once the skin is prepared, the DermaPen is used to carry out the microneedling whilst the Polynucleotide product is applied directly onto the skin’s surface. It is not injected at any point. The sensation is typically described as a mild warming or tingling feeling.
Following treatment, it is normal to experience:
- Redness and mild sensitivity, similar in appearance to light sunburn
- Some tightness or minor swelling in the treated area
- Slight peeling or flaking as the skin begins to renew itself
These are all signs that the skin is actively healing. Most clients are able to return to work and daily activities within 48 hours. You will be provided with full aftercare instructions to support your recovery and maximise your results.
Prices
| Product Used | Device Used | Prices |
|---|---|---|
| DermaQuest / Obagi / Dr Levy Range | Aloe Vera Mask | DPM8 Dermapen / Disposable 16pin Needle Cartridge | £225 |
FAQs
- Is DermaPen Microneedling with Polynucleotides painful?
Topical numbing cream is applied prior to treatment, so most clients experience only a mild warming sensation during the procedure. Discomfort is minimal, and the majority of clients tolerate the treatment very well.
- How soon will I see results?
Some improvement in skin radiance and texture can be noticed after the first session. However, the most significant and transformative results become visible progressively over the course of a full treatment plan, as the skin’s collagen production increases and the Polynucleotides support ongoing cellular regeneration.
- Is there any downtime?
There is minimal downtime associated with this treatment. Most clients experience redness and mild sensitivity for 24-48 hours following the session. With the correct aftercare, the majority of clients are comfortable returning to their normal routine within two days.
- Can this treatment be combined with others?
Yes. We may recommend combining DermaPen Microneedling with Polynucleotides with other treatments as part of a comprehensive skin rejuvenation plan. This will be discussed and tailored to your specific skin concerns during your consultation.
- Is this treatment safe for darker skin tones?
Yes. DermaPen Microneedling with Polynucleotides is suitable for all skin tones, including deeper Fitzpatrick skin types. This makes it a particularly well-suited option for treating hyperpigmentation and acne scarring on melanin-rich skin.
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